Fettah ERDOĞAN

If you are passionate about integrating structural biology, AI, and biophysical chemistry to drive innovation in precision medicine and translational research, you have come to the right place!

Biological and Biophysical Chemistry

Research Focus: Therapeutic Protein Target Prioritization & Tractability Validation

• Dr. Erdogan’s lab works on designing and utilizing machine learning algorithms to analyze chemoproteomics datasets and identify novel druggable sites

• These projects utilize various chemical and structural biology techniques to empirically validate predictions that may lead to uncovering novel therapeutic drug targeting modalities.

Structural and Computational Biology

Research Focus: Structure-Function Relationship Disease-linked Protein Variants

• Dr. Erdogan’s team also investigates disease-associated mutations and their impact on protein structure and function through various biochemical and biophysical methods.

Research Techniques

• Applications of techniques in recombinant protein production, X-ray crystallography, bioinformatics, biochemical and biophysical assays.

Publications

A selection of key publications:

• Erdogan F.* et al. Structural and mutational analysis of member-specific STAT functions. Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130058.

doi: https://doi.org/10.1016/j.bbagen.2021.130058

• de Araujo, E.D., Erdogan, F.* et al., Structural and functional consequences of the STAT5BN642H driver mutation, Nat. Commun. 10, 2517. 2019.

doi: https://doi.org/10.1038/s41467-019-10422-7

• Erdogan, F.* et al., JAK-STAT Core Cancer Pathway: An Integrative Cancer Interactome Analysis, J. Cell. Mol. Med. 26 (7), 2049–2062. 2022.

doi: https://doi.org/10.1111/jcmm.17228

• Olaoye, O.O., Erdogan, F.* et al., Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications, J. Med. Chem. 68 (17), 18216–18229. 2025.

doi: https://doi.org/10.1021/acs.jmedchem.5c00479

All Publications

Awards & Highlights

• Mitacs Accelerate Research Grant (2024)
• TUBITAK International Fellowship for Early Stage Researchers (2025)